Báo cáo khoa học: Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways Based on The Anniversary Prize of the Gesellschaft fu¨r Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels

Integrating Signals Between cAMP and the RAS/RAF/MEK/ERK Signalling Pathways

Authors:

Nicolas Dumaz and Richard Marais

Field:

Signal Transduction Team, Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, London, UK

Document Content:

This review article explores the intricate crosstalk between the cyclic adenosine monophosphate (cAMP) and the RAS/RAF/mitogen-activated protein kinase (MAPK) signaling pathways. It delves into the molecular mechanisms underlying the interactions between these two ancient and conserved pathways, and discusses their potential biological significance. The article highlights how cAMP can either inhibit or stimulate cell proliferation depending on the cell type, largely attributed to crosstalk with the RAS/RAF/MAPK and extracellular signal-regulated kinase (ERK) pathways. The authors review the complex regulatory mechanisms and biological consequences of these interactions, providing insights into how cells respond to their environment and maintain homeostasis. Disrupted signaling in these pathways is implicated in various diseases, including cancer and diabetes.

Detailed Table of Contents:

• Introduction
• The cAMP Signalling Pathway
• The RAS/RAF/MEK/ERK Signalling Pathway
• RAF is activated by membrane recruitment and phosphorylation
• Inhibition of RAS–ERK signalling by cAMP
• The role of 14-3-3 in C-RAF regulation by cAMP
• A model of C-RAF regulation by cAMP
• Inhibition of proliferation by cAMP
• CAMP-stimulated activation of ERK in proliferation and differentiation
• PC12 cells
• Melanocytes/melanoma
• Thyroid cells
• Conclusion
• References
• Acknowledgements