Báo cáo khoa học: Protein tyrosine phosphatases: functional inferences from mouse models and human diseases

Protein tyrosine phosphatases: functional inferences from mouse models and human diseases

Authors: Wiljan J. A. J. Hendriks, Ari Elson, Sheila Harroch, and Andrew W. Stoker

Field: Molecular Biology, Genetics, Cell Biology

Document Content: This minireview provides an overview of the roles of protein tyrosine phosphatases (PTPs) in cellular signaling pathways, development, and disease, drawing insights from both mouse models and human studies. It highlights how the generation of animal model systems and the investigation of various human diseases have begun to elucidate the significant and diverse functions of PTPs. The review also touches upon novel approaches being utilized to deepen the understanding of this enzyme family and their growing involvement in human pathologies, positioning them as potential drug targets.

Detailed Table of Contents:

• Keywords
• Correspondence
• Reversible tyrosine phosphorylation
• PTP function: animal models lead the way
• Knockout intercrosses: less is more
• Table 1. Phosphotyrosine-specific class I PTP-related phenotypes in mouse and human.
• Customizing PTP expression
• Oncogenic as well as tumour-suppressive PTPs
• PTPs in the immune system
• Attractive new ways to address PTP function
• Conclusion
• Acknowledgements
• References