Báo cáo khoa học: Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric G proteins

Submembraneous Microtubule Cytoskeleton: Regulation of Microtubule Assembly by Heterotrimeric G Proteins

Authors:

Sukla Roychowdhury and Mark M. Rasenick

Field:

Neuroscience and Metabolic Disorder Unit, Border Biomedical Research Center and Department of Biological Sciences, University of Texas, El Paso, TX, USA; Department of Physiology and Biophysics, Psychiatry, University of Illinois, Chicago, IL, USA

Document Content:

This review delves into the intricate relationship between heterotrimeric G proteins and the microtubule cytoskeleton. It explores how G protein subunits, specifically α and βγ, interact with tubulin and microtubules to regulate their assembly and dynamics. This interaction offers a novel mechanism for rapid cytoskeletal remodeling in response to hormones or neurotransmitters, crucial for cell division, neuronal differentiation, and synaptic plasticity. The document highlights the role of G proteins in processes such as mitotic spindle formation, centrosome/chromosome movement, and neurite outgrowth, emphasizing the structural plasticity mediated by microtubules.

Detailed Table of Contents:

• Keywords
• Correspondence
• Abstract
• Introduction
• Beyond transmembrane signaling: the interaction of G proteins with microtubules
• Regulation of microtubule assembly by α and βγ subunits of G proteins
• γ-Tubulin-Gβγ interactions and microtubule nucleation
• Cellular and physiological aspects of G protein-microtubule interactions
• Organization and function of mitotic spindle during cell division
• Neuronal differentiation
• Acknowledgements
• References