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Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent

Authors: Kenji Takeuchi, Yu-ichiro Motoda, and Fumiaki Ito

Field: Biochemistry, Pharmaceutical Sciences

Document Content: This research investigates the protective role of epidermal growth factor (EGF) against apoptosis induced by adriamycin (ADR) in human gastric adenocarcinoma TMK-1 cells. The study reveals that EGF treatment significantly reduces ADR-induced apoptosis by upregulating the expression of Bcl-XL, an antiapoptotic protein. This upregulation is mediated by the activation of the transcription factor activator protein 1 (AP1) through a MAP kinase signaling pathway. The findings highlight a novel EGF-induced cell survival mechanism involving AP1 and Bcl-XL, which is crucial for protecting cells from DNA-damaging agents.

Detailed Table of Contents:

  • Abstract
  • Keywords
  • Correspondence
  • Introduction
  • Materials and Methods
  • Results
  • Discussion
  • Experimental Procedures
  • References