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Progress for Dengue Virus Diseases Towards the NS2B-NS3pro Inhibition for a Therapeutic-Based Approach

Authors: Sonia Melino and Maurizio Paci

Field: Chemical Science and Technology

Document Content: This review article examines the progress in understanding and combating dengue virus diseases, with a particular focus on the NS2B-NS3pro protease inhibition as a therapeutic strategy. Dengue, a significant global health concern transmitted by the Aedes aegypti mosquito, causes dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Despite the absence of approved vaccines, research is advancing towards therapeutic interventions. The NS3 protease domain of the NS3 protein plays a crucial role in viral polyprotein processing, making it a primary target for pharmacological therapy. This review provides an overview of the structural and functional aspects of the NS3 protease and its inhibition for the treatment of dengue virus infections.

Detailed Table of Contents:

  • Keywords
  • Correspondence
  • Abstract
  • Introduction to Dengue Virus and its Impact
  • Virus Structure and Replicative Cycle
  • Genome Organization
  • Polyprotein and Processing
  • Structural Proteins
  • Non-structural Proteins
  • Dengue vaccine: a possible solution to DENv infection
  • Therapeutic approaches – NS3 protease inhibition as a response to DENv
  • Structural and functional studies on NS3 protease
  • Substrate specificity of NS2B-NS3pro
  • Inhibition of NS3 protease, a therapeutic target
  • Conclusions
  • Acknowledgements
  • References