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Origins of DNA replication in the three domains of life

Authors: Nicholas P. Robinson and Stephen D. Bell

Field: Molecular Biology, Genetics

Document Content:

This review article explores the fundamental process of DNA replication across the three domains of life: Bacteria, Eukarya, and Archaea. It details the diverse mechanisms employed by cellular organisms to ensure accurate genome duplication. The article delves into the identification and characteristics of replication origins, the proteins involved in initiation, and the structural and functional aspects of replication machinery. Comparisons are drawn between the three domains, highlighting both conserved principles and unique adaptations in origin definition and activation. The role of epigenetic factors and protein-DNA interactions in regulating replication initiation is also discussed.

Detailed Table of Contents:

  • Review Article: Origins of DNA replication in the three domains of life
  • Keywords: Cdc6; DnaA; DNA Replication; MCM; ORC
  • Correspondence
  • The origin of origins
  • Bacteria
  • Eukaryotic origins
  • Lessons from budding yeast
  • Origins in other eukaryotes
  • Archaea
  • Acknowledgements
  • References