Báo cáo khoa học: ER stress and diseases

ER Stress and Diseases

Author: Hiderou Yoshida

Field: Biophysics, Graduate School of Science, Kyoto University, Japan; PRESTO-SORST, Japan Science and Technology Agency, Japan

Document Content:
This review article focuses on the endoplasmic reticulum (ER) stress response and its implications in various diseases, particularly ‘conformational diseases’. It details how the ER, responsible for protein synthesis and folding, activates a defense mechanism, the ER stress response, when overwhelmed by unfolded or malfolded proteins. This response involves attenuation of protein synthesis, induction of ER chaperones and ER-associated degradation (ERAD) components, and apoptosis. The article elaborates on the molecular pathways regulating this response, including the PERK, ATF6, and IRE1 pathways. It further explores the involvement of ER stress in neurodegenerative diseases like Alzheimer’s and Parkinson’s, polyglutamine diseases, bipolar disorder, diabetes mellitus, and atherosclerosis, highlighting how disruptions in protein homeostasis and the subsequent ER stress contribute to the pathogenesis of these conditions. Molecules that modulate the ER stress response are presented as potential therapeutic targets.

Detailed Table of Contents:

• REVIEW ARTICLE
• ER stress and diseases
• Keywords
• Correspondence
• Abbreviations
• Introduction
• ER stress-inducing chemicals
• ER chaperones
• ERAD
• Response pathways for ER stress
• PERK pathway
• ATF6 pathway
• IRE1 pathway
• Apoptosis-inducing pathways
• ER stress-related diseases
• Neurodegenerative diseases
• Bipolar disorder
• Diabetes mellitus
• Atherosclerosis