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CREB And cAMP Response Element-Mediated Gene Expression In The Ischemic Brain

Author: Kazuo Kitagawa

Field: Stroke Division, Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

Document Content:

This minireview delineates the crucial role of CREB (cAMP response element-binding protein) in regulating gene expression within the ischemic brain. Cerebral ischemia triggers the activation of CREB, leading to the expression of genes that confer neuroprotection and aid in neuronal survival. The review highlights CREB’s involvement in ischemic tolerance, neurogenesis in the hippocampus, and its potential as a therapeutic target for promoting functional recovery in stroke patients. It synthesizes current understanding of CREB’s mechanisms and its significance in the context of cerebral ischemia.

Detailed Table of Contents:

  • Introduction
  • Intracellular signaling in the ischemic stress
  • CREB phosphorylation and CRE-mediated gene expression in ischemic brain
  • Significance of CRE-mediated gene expression in the ischemic brain
  • Role of CREB in neurogenesis after ischemia
  • Future aspects