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What Does It Mean To Be Natively Unfolded?

Author: Vladimir N. Uversky

Field: Biochemistry, Biophysics

This review article explores the nature of natively unfolded proteins, a distinct category within the protein kingdom. These proteins, characterized by a lack of stable three-dimensional structure under physiological conditions, challenge traditional notions of protein function. The article synthesizes existing research to delineate their key structural and conformational properties, including low hydrophobicity, high net charge, and significant flexibility. It also discusses their unique responses to environmental changes and their potential roles in biological processes and diseases.

Detailed Table of Contents:

  • What are Natively Unfolded Proteins?
  • Why Study Intrinsically Disordered Proteins?
  • Why Are Intrinsically Disordered Proteins Unfolded?
  • What Are the General Structural Characteristics of Natively Unfolded Proteins?
  • Environmental Influences on the Natively Unfolded Proteins
  • What Else Is Required for Intrinsically Unordered Proteins to Fold?
  • Conclusions