Báo cáo khoa học: Signal Transduction

Signal Transduction

Tên đề tài: Signal Transduction

Tác giả: Các tác giả được liệt kê trong từng bài tóm tắt.

Lĩnh vực: Sinh học Phân tử, Tế bào, Y sinh.

Nội dung tài liệu:

Tài liệu này là một tập hợp các bài tóm tắt các nghiên cứu khoa học liên quan đến lĩnh vực “Signal Transduction” (Truyền tín hiệu). Các nghiên cứu bao gồm nhiều khía cạnh khác nhau của truyền tín hiệu tế bào, từ các cơ chế phân tử ở cấp độ gen và protein đến các quá trình sinh lý phức tạp hơn như sự phát triển, biệt hóa tế bào, phản ứng với các tác nhân kích thích, và các bệnh lý liên quan.

Nội dung của các bài tóm tắt đề cập đến các chủ đề đa dạng như: điều hòa biểu hiện gen thông qua các yếu tố phiên mã và các biến đổi histone, vai trò của các phân tử tín hiệu như glutathione, protein kinase, hormone, các yếu tố tăng trưởng, và các con đường truyền tín hiệu phức tạp như MAPK, PI3K/Akt, Wnt, TGF-β. Các nghiên cứu cũng khám phá cơ chế hoạt động của các protein quan trọng trong các quá trình tế bào, ví dụ như Runx, Dpp, MGP, GCP1, PLD1, PTPe, TrkA, SIVA, PDCD2, NF1, Smad, TCFs, Groucho, PLA2, TEGT, Kidins220, Hippocalcin, Skn7, và nhiều loại khác.

Các mô hình nghiên cứu được sử dụng bao gồm các loài sinh vật khác nhau như C. albicans, C. elegans, D. discoideum, Drosophila, Xenopus laevis, Arabidopsis thaliana, H19-7 cells, HEK293 cells, NIH3T3 cells, PC12 cells, HeLa cells, NB4 cells, HUVEc cells, CHO cells, HaCaT cells, HT29 cells, MDA-MB-453 cells, 3T6 fibroblasts, RAW 264.7 cells, B-CLL cells, neuroblastoma cells, thyroid tumors, lymphoma cells, endometrial carcinoma cells, prostate cancer PC-3 cells, macrophages, neutrophils, và các dòng tế bào ung thư khác nhau. Các phương pháp nghiên cứu đa dạng được áp dụng, bao gồm phân tích di truyền, sinh hóa, miễn dịch hóa học, nuôi cấy tế bào, kỹ thuật hình ảnh, và mô hình toán học.

Mục lục chi tiết:

• C1-1 Histone modifications regulate morphogenesis in C. albicans
• C1-2 Glutathione regulates the transition from growth to development in Dictyostelium discoideum
• C1-3 Tissue-specific regulation of RNT-1 function in C. elegans
• C1-4 Differential cleavage of Dpp precursor modulates morphogen gradient in the Drosophila
• C1-5 Phenotypic observation of Xenopus laevis MGP loss of function
• C1-6 Lachesis restricts gametic cell fate in the female gametophyte of Arabidopsis
• C1-7 Cytokinine secondary hormone activates plasmatic membrane H+-ATPase which is important regulatory machine of the plant cell
• C1-8 Mathematical model of the Arabidopsis thaliana morphogenesis in a cellular automaton terms
• C1-9 The highly conserved mitochondrial protein GCP1 is essential for embryo development in Arabidopsis thaliana
• C1-10 Phospholipase D1 regulates neurogenin1 expression via mTOR during bFGF-induced neurite outgrowth in H19-7cells
• C1-11 Tyrosine phosphatase epsilon is a negative regulator of the signal transducer Shc
• C1-12 TRKA induction leading to cell death via cell cycle alteration and γH2AX accumulation in cytosol
• C1-13 Identification of SIVA and PDCD2 as novel XIAP interaction partners
• C1-14 NF1 and Smad proteins, are they partners?
• C1-15 VEGF induces a specific gene repertoire in endothelial cells
• C1-16 Functional analysis of a homeobox gene upregulated by VEGF in endothelial cells
• C1-17 Signaling events downstream of MuSK and their role during neuromuscular synapse formation
• C1-18 Cell-specific control of Wnt target genes: role of epigenetic modifications and differential promoter binding by TCFs
• C1-19 Canonical Wnt signalling and Groucho proteins affect left-right asymmetry
• C1-20 PLA2 is important in phosphatidic acid-induced Bcl-2 expression through ERK1/2 MAPK activation
• C1-21 Inhibitors of protein kinase A, protein kinase C and MAP kinases enhance the IL-13-induced expression of IL-6 by nasal polyp fibroblasts
• C1-22 Endothelin-1 activates Glut1 transcription via both PKC’s and MAPK signaling pathways
• C1-23 Effect of growth factors on acetaminophen-induced liver injury
• C1-24 Role of PKCε in Gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells
• C1-25 Prion protein at the interface of MAPK and TGF-beta signaling
• C1-26 Supportive evidence of desmin’s role in TGF-B signaling and early cardiomyogenesis
• C1-27 Dynamics of S100A11 protein in human myoblasts after stimulation of differentiation
• C1-28 Studying the role of tissue transglutaminase in neutrophil granulocyte differentiation
• C1-29 Role of protein L-isoaspartyl o-methyltransferase in neuronal differentiation of P19 embryonal carcinoma
• C1-30 Interaction between the neurotrophin receptor target kidins220 and the ERM membrane-cytoskeleton linker protein Moesin
• C1-31 Kidins220: A novel neuronal protein that is up-regulated during neuroblastoma differentiation
• C1-32 A novel role for hippocalcin in bFGF-induced neurite outgrowth of H19-7 cells
• C1-33 IL6 inhibits RANKL-induced osteoclastogenesis by diverting cells into the macrophage lineage: implication of STAT3
• C1-34 Expression and role of α6 integrin in the early embryo
• C1-35 Opioids in epilepsy: lessons from prodynorphin KO mice
• C1-36 The biological significance of novel CK1-mediated phosphorylation of tau protein and its associated proteins in rat brain
• C1-37 IL-1beta upregulates Smad7 via NFkB activation in human chondrocytes
• C1-38 Neurosteroids protect neural-crest derived cells from apoptosis, tempospatially activating prosurvival kinases
• C1-39 Transcriptional regulation of the small GTPase RhoB gene by the transforming growth factor β signaling pathway
• C1-40 Expression and function of arylhydrocarbon receptor in growth plate chondrocytes
• C1-41 TEGT suppresses stress-induced apoptosis and shows differential mRNA expression during early development
• C1-42 An autocrine mechanism leads to productive effector-coupling of the A2A adenosine receptor in SH-SY5Y neuroblastoma cells
• C1-43 Structure of a survivin-borealin-INCENP core complex reveals how chromosomal passengers travel together
• C1-44 Increased stability compensates for lower heparin-binding affinity of FGF-1 mutants
• C1-45 Investigation of the phagocytosis signaling in tissue transglutaminase deficient macrophages
• C1-46 Nitric oxide synthase expression in synchronized and asynchronous cell cultures
• C1-47 Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or VDAC
• C1-48 Enantioselective effect of 12(S)-HETE on 3T6 fibroblast growth
• C1-49 The 3rd intracellular loop of somatostatin receptor 5 is crucial for arrestin binding and receptor internalization
• C1-50 Activation of protease-activated receptors 2 (PAR-2) of HT29 cells by abzymes from breast milk
• C1-51 Estrogen-induced vascular lesions formation is mediated by redox sensitive Id3 signaling
• C1-52 Pro- and antioxidant properties of mitochondria-targeted antioxidant mitoQ
• C1-53 Calcium-dependent interaction of calmodulin with synapse-associated proteins of the MAGUK family
• C1-54 BMI inversely correlates with PKA expression and activity in adipocytes from lean and obese subjects
• C1-55 Voltage-gated calcium channel dependent intracellular signaling
• C1-56 Liposomes as possible carriers for anti-inflammatory and antitumoral compounds
• C1-57 Investigation of rapid nongenomic effects of 1α,25(OH)2D3 on intracellular calcium in human peripheral blood mononuclear cells
• C1-58 The homeodomain factor Xanf can bind with the LIM-domain protein Zyxin in early development of the neural plate of Xenopus laevis
• C1-59 Creation/implementation of clinically relevant high-grade glioma mouse models for optimizing chemotherapeutic treatment
• C1-60 Skn7 regulates the formation of germ tube by binding the promoter of some hypha-specific genes in Candida albicans
• C1-61 Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model
• C1-62 Phospholipase D is important in Der f 2 induced expression of IL-8 and IL-13 in human bronchial epithelial cells
• C1-63 Synergistic effects and reversible inhibition of cAMP-dependent protein kinase catalytic subunit
• C1-64 Ghrelin signaling to ERK 1/2: role of G-proteins and beta-arrestins
• C2-1 Deciphering the kinome in basal-like breast carcinoma for therapeutic usefulness
• C2-2 P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling
• C2-3 Ceramide production is involved in capsaicin-induced apoptosis in the androgen-independent prostate cancer PC-3 cells
• C2-4 TCTP induced signaling pathways
• C2-5 NPM-ALK induces JUNB and converts its role from a tumor suppressor to an oncogene
• C2-6 Translational control of JUNB via the fusion tyrosine kinase NPM-ALK in ALC(L) lymphoma
• C2-7 BRAF V600E mutation and oncogenic activation of MAP kinase by its pseudogene in thyroid tumors
• C2-8 Valproic acid modulates cell motility and MAP-kinase activity in a cell type-specific manner
• C2-9 In vitro studies of nuclear fraction of leukemic cells treated with anticancer drug(s) by thermal technique
• C2-10 Pro-apoptotic activity of different purine derivatives in B-CLL cells
• C2-11 FKHRL1 leads to re-expression of caspase 8 in neuroblastoma cells
• C2-12 Equol induces apoptosis through cytochrome c-mediated caspase cascade in breast cancer MDA-MB-453 cells
• C2-13 Induction of cytotoxicity and apoptosis in HT-29 cells by a gleditsiae semen extract
• C2-14 Epoxyeicosatrienoic acids induce apoptosis in 3T6 fibroblast cultures through calpain/caspase cascades
• C2-15 Effect of usnic acid on tissue caspase activity and glutathione level in titanium-implanted subjects