Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide

The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide

Tác giả: Douglas L. Currell and Jack Levin

Lĩnh vực: Biochemistry, Medicine

Nội dung tài liệu: This study investigates the impact of bacterial lipopolysaccharide (LPS) on the oxidation of human hemoglobin (Hb). The research compares the effects of smooth and rough LPS from Escherichia coli and Salmonella minnesota on both native and cross-linked human hemoglobin. The findings indicate that LPS binding can accelerate Hb oxidation, potentially impacting the efficacy of Hb-based oxygen carriers. The study also explores the role of heavy metal cations, particularly cupric ion, in this oxidative process.

Mục lục chi tiết:

• Introduction
• Materials and Methods
• Results
• Discussion
• Acknowledgements
• References