Báo cáo khoa học: The spread of prions through the body in naturally acquired transmissible spongiform encephalopathies

The Spread of Prions Through the Body in Naturally Acquired Transmissible Spongiform Encephalopathies

Authors: Michael Beekes and Patricia A. McBride

Field: Veterinary Medicine, Neuroscience, Molecular Biology

Document Content:
This review provides an overview of the current understanding of how agents of transmissible spongiform encephalopathies (TSEs), such as scrapie, chronic wasting disease, bovine spongiform encephalopathy, and variant Creutzfeldt-Jakob disease, spread through the body in naturally infected hosts and in experimental models. It details the pathways and tissue components involved in prion routing, including intestinal uptake, neuroinvasion, and spread from the central nervous system to peripheral sites. The study of these pathways is crucial for developing effective infection control strategies, improving diagnostic methods, and identifying prophylactic or therapeutic approaches to combat these fatal neurodegenerative diseases.

Detailed Table of Contents:

• Introduction to Transmissible Spongiform Encephalopathies (TSEs)
• Routes of Infection in Naturally Acquired Prion Diseases
• Exploration of the Systemic Spread of Infection in Naturally Acquired TSEs
• Prion Routing Following Natural Infection or Experimental Peroral Challenge: Involved Tissue Components and Pathways of Spread
• Lymphoid Involvement in Pathogenesis
• Scrapie and BSE in Laboratory Rodents
• Neuroinvasion, Sympathetic and Parasympathetic Spread to the CNS, and Propagation from the Brain and Spinal Cord to Peripheral Nervous System Components
• Scrapie in Laboratory Rodents
• Scrapie and BSE in Sheep
• CWD in Elk and Deer
• BSE in Cattle
• BSE in Primates
• vCJD in Humans
• Infection of Muscles
• Blood Borne Dissemination of Prions
• The Influence of Inflammation on the Propagation of Prion Infection
• Mechanisms of Prion Propagation in the Nervous System
• Concluding Remarks and Outlook